ACUTE PROMYELOCYTIC LEUKAEMIA (APL)

t(15;17) Translocation

Acute promyelocytic leukaemia (APL) is a distinct form of acute myeloid leukaemia (AML) characterised by the t(15;17) translocation, involving the PML and RARA genes, in more than 90% of cases (Kakizuka et al. 1991 Cell 66:663–674). This translocation can be identified by Real-Time PCR using primers and probes which amplify across the common breakpoint regions (Gabert et al. 2003 Leukemia 17:2318-2357).

Laboratory contact: Dr Caroline Wickham 01392 408252 caroline.wickham@nhs.net

Clinical contact: Dr Paul Kerr 01392 402917 paul.kerr1@nhs.net

The laboratory participates in the NEQAS LI BCR-ABL and AML Translocation Identification Programme.