ACUTE PROMYELOCYTIC LEUKAEMIA (APL)

t(15;17) Translocation

Acute promyelocytic leukaemia (APL) is a distinct form of acute myeloid leukaemia (AML) characterised by the t(15;17) translocation, involving the PML and RARAα genes. This translocation can be detected in more than 90% of cases of APL (Kakizuka et al. 1991 Cell 66:663–674). PML-RARα fusion gene transcripts are detected using Real-Time PCR to amplify across the common breakpoints.

(Gabert et al. 2003 Leukemia 17:2318-2357).

Laboratory contact: Dr. Caroline Wickham 01392 408248 caroline.wickham@nhs.net

Clinical contact: Dr. Paul Kerr 01392 402917 paul.kerr1@nhs.net

The laboratory participates in the NEQAS BCR-ABL and AML Translocation Identification Programme.