FOLLICULAR LYMPHOMA

t(14;18) TRANSLOCATION

The t(14;18) translocation is found in approximately 80-90% of follicular lymphomas and 30% of diffuse large cell lymphomas, it is rarely present in other lymphoproliferative diseases (van Dongen (2003) Leukemia 17, 2257–2317). The t(14;18) translocation has also been reported in “lymphoma free” individuals, in particular men over the age of sixty and heavy smokers. It has also been detected in Epstein-Barr virus infected cells. t(14;18) translocation analysis can therefore be used as a tool in the differential diagnosis of follicular lymphoma. However, all molecular data must be interpreted with other histological and clinical data.

Laboratory contact: Dr Caroline Wickham 01392 408252 caroline.wickham@nhs.net Clinical contact: Dr Paul Kerr 01392 402917 paul.kerr1@nhs.net

The laboratory participates in the European Molecular Genetics Quality Network (EMQN) sequencing scheme.