HOLOPROSENCEPHALY

SHH, ZIC2, SIX3, PTCH1, GLI2 AND TGIF1 GENE ANALYSIS

Nonsyndromic Holoprosencephaly (HPE) (OMIM 236100) is a structural anomaly of the brain in which there is failed or incomplete separation of the forebrain (prosencephalon) early in gestation. It can be grouped into four types according to the degree of brain division: