Serum for GAD, IA-2 and ZnT8 testing only (minimum 500 µL serum): Please send with your local Pathology request form to Blood Sciences Laboratory.
First class post at room temperature
ZnT8 age >/= 30 yrs Positive: >/= 10 U/mL.
ZnT8 age <30 yrs Positive: >/= 65 U/mL.
£29.04 (all three antibodies)
Autoantibodies recognising the islet cell antigens glutamic acid decarboxylase (GAD 65), Zinc Transporter 8 (ZnT8) and the insulinoma antigen 2 (IA-2) are present in up to 90% of newly diagnosed patients with type 1 diabetes. The prevalence of GAD, IA-2 and ZnT8 autoantibodies is less than 1% in GCK, HNF1A and HNF4A MODY, and testing for these autoantibodies close to diagnosis gives very good discrimination of Type 1 diabetes from MODY (McDonald et al 2011 Diabet Med 28:1028-1033). The Blood Sciences department at the Royal Devon & Exeter Hospital offers a highly sensitive, automated ELISA method for the quantitative determination of GAD, IA-2 and ZnT8 autoantibodies in both serum (preferred sample type) and plasma samples.
10 working days
We welcome referrals for ZnT8 testing. If you are a new requestor please complete the following form: New requestor form
We now also have the option to use NPEx for referral requesting.
Further information about sample requirements for this test can be found here: GAD IA2 ZnT8 – further information
This investigation is performed at the Royal Devon & Exeter Hospital (Wonford)