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Triglycerides

Blood Sciences Test


Specimen

Serum (Fasting or non-fasting)

Units

mmol/L

Test Usage

Triglyceride in the fasting state comes from the liver in VLDL particles and their smaller IDL products. When triglyceride metabolism is markedly impaired, chylomicrons can be present in the fasting state. If the fasting triglyceride is above 5 mmol/L, the specimen will appear cloudy due to raised VLDL and/or chylomicrons which rise to form a creamy layer on standing.

Causes of elevated fasting triglyceride

Secondary Causes:

Obesity, alcohol, diabetes, hypothyroidism, liver disease (particularly obstructive), nephrotic syndrome, pancreatitis, pregnancy, significant illness, drugs (oestrogens, oral contraceptives, beta blockers, corticosteroids, thiazides, retinoic acid, anti-viral agents, valproic acid).

Primary Lipidaemias:

Familial combined hyperlipidaemia; familial hypertriglyceridaemia; type III (“remnant removal disease”) hyperlipoproteinaemia

Interpretation of triglycerides:

Limit mmol/L Comments
<10 For interpretation of Triglyceride concentration, refer to NICE Clinical Guideline 181 Lipid Modification 2014.
>=10 Hypertriglyceridaemia noted. Triglycerides greater than 10 mmol/L are associated with an increased risk of acute pancreatitis. If this result is unexpected, a repeat fasting sample after an interval of five days but within two weeks is suggested. For known diabetic patients, review glycaemic control before considering repeat test. For interpretation of Triglyceride concentration, refer to NICE Clinical Guideline 181 Lipid Modification 2014.
>=20 Gross hypertriglyceridaemia noted. Triglycerides greater than 20 mmol/L require urgent review by a lipid specialist if not caused by acute excess alcohol or poor glycaemic control. For interpretation of Triglyceride concentration, refer to NICE Clinical Guideline 181 Lipid Modification 2014.

Turnaround time

1 day

Availability

Local test

Can be added on to an existing request up to 4 days following sample receipt

 

Specimen Labelling Procedure
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8210

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