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Urine Cytology

Cellular Pathology

Principle of Examination

Urine cytology samples are repeatable, non-invasive initial investigations performed either for diagnosis of malignancy or as routine post operative or treatment follow up. Urine cytology has a high sensitivity for high grade transitional cell carcinomas which can appear normal on cystoscopy.

Specimen Requirements

When sending urine samples for cytological investigation, please note the following:

  • Please do not send early morning urine.
  • Whole output second urine is required in a sterile suitable container. We regret that we are unable to accept specimens in drainage bags or leaking containers.
  • There should be adequate clinical information provided on the request, which should clarify the indication for a cytological examination.
  • State on the request whether the specimen is a voided or catheter specimen.
  • Indicate on the request if there is a history of relevant foreign travel.
  • Samples should be sent to laboratory as soon as possible for processing, preferably within 24 hours.
  • Send a separate specimen and request form to Microbiology if a microbiological investigation is required.

Specimen Delivery and Labelling

All Trust specimens must be requested on Epic and labelled with an Epic label. GPOCS specimens must be labelled with a GPOCs label. All other samples must have a request form.

HIGH RISK SPECIMENS: Requests must indicate if a specimen is high risk.  Please indicate details of the risk, eg: TB, blood-borne virus, etc.

URGENT SPECIMENS: Please label urgent specimens clearly; an explanation as to why the specimen is urgent is helpful.  On receipt, laboratory staff will notify the pathologist who will report the specimen as soon as possible.

Turnaround Time

The Laboratory aims to comply with The Royal College of Pathologists Key Performance Indicator (KPI 6.4) for Cellular Pathology reporting turnaround times with 90% of all cases reported within 10 calendar days.



Specimen Labelling Procedure
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