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Aspergillosis

Microbiology


universal

Specimen

Culture: Nose Swab, Tissue biopsy, Broncho-alveolar lavage (BAL),Blood Cultures

Serology/PCR: Blood

Specimen container

  • Nose swab –  Transwab
  • Biopsy, BAL –  Plain Universal Sterile Universal Pot
  • Serology  –  Gold top tube
  • Blood Culture Bottles – Aerobic and Anaerobic

Special Instructions

Usually only relevant in immunocompromised patients.

Test Usage

Aspergillus Antibody (precipitins)

Detection of antibodies to Aspergillus spp. Appropriate for the diagnosis of aspergillosis in immunocompetent patients e.g. allergic bronchopulmonary aspergillosis, aspergilloma, chronic necrotising aspergillosis, aspergillus sinusitis

 Aspergillus antigen

This test detects the presence of the Aspergillus antigen galactomannan in serum or BAL fluid to diagnosis invasive aspergillosis in immunocompromised patients.

Aspergillus PCR

Detects presence of Aspergillus DNA in whole blood or BAL fluid. Generally used serially to detect rising levels post-bone marrow transplant.

Availability

Culture – tested at RDE

PCR/ Serology – sent to Reference laboratories

Reference Laboratory

Aspergillus Ag / Precipitins /PCR – Bristol PHE laboratory

Processing Time

Culture – up to 2 weeks

Serology/ PCR – up to 1 weeks

Urgent Specimen Instructions

D/W Consultant Microbiologist

Specimen Labelling Procedure Procedure for Collection of Blood Cultures
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