GENETIC TESTING OF THE DPYD GENE TO PREDICT TOXICITY IN PATIENTS TREATED WITH 5-FLUOROURACIL (5-FU) BASED CHEMOTHERAPY The fluoropyrimidines 5-fluorouracil (5-FU) and capecitabine are widely used in the treatment of solid tumours. Approximately 10–40% of fluoropyrimidine-treated patients develop severe and sometimes life-threatening toxicity (neutropenia, nausea, vomiting, severe diarrhoea, stomatitis, mucositis, hand-foot syndrome) (Amstutz et al. […]
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