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"5-flurouracil toxicty"



PREDICTION OF 5-FLUOROURACIL TOXICITY

Category: Genomics Oncology

GENETIC TESTING OF THE DPYD GENE TO PREDICT TOXICITY IN PATIENTS TREATED WITH 5-FLUOROURACIL (5-FU) BASED CHEMOTHERAPY The fluoropyrimidines 5-fluorouracil (5-FU) and capecitabine are widely used in the treatment of solid tumours. Approximately 10–40% of fluoropyrimidine-treated patients develop severe and sometimes life-threatening toxicity (neutropenia, nausea, vomiting, severe diarrhoea, stomatitis, mucositis, hand-foot syndrome) (Amstutz et al. […]

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PREDICTION OF 5-FLUOROURACIL TOXICITY

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17-hydroxyprogesterone 17-OH progesterone 17-OHP 17α-hydroxyprogesterone 21 hydroxylase 21-OH 3-methoxytyramine 5-flurouracil toxicty Aarskog-scott syndrome AAS ABCC6 ABCC8 Academic Department status acid maltase Acid maltase deficiency acyclovir ADAMTS13 admab AGPAT2 AGPS AIP Alagille Syndrome ALP Alpha-galactosidase A deficiency amikacin amino acid Anderson-Fabry aneuploidy anomoly anti-thyroglobulin antithyroglobulin ARSE AstraZeneca) BANF1 Bilharzia Biotin Blood Sciences BNP Bone bone profile BRAF BSCL2 CA-153 CA125 CA15.3 CA153 CA19-9; CA199; CA-199 CADASIL cancer Carney Complex CASR CAV1 CDC73 CFT CGL chance Chondrodysplasia punctata ciprofloxacin Clotted Blood co-trimoxazole COL4A1 COL4A2 colistin Congenital Generalised Lipodystrophy Congenital Hypothyroidism Coronavirus Covid cycloserine daptomycin Deafness DG30 Diabetes diarrhoea DLL3 DMP1 Down's syndrome DPYD EBP EBV Edward's syndrome EFTUD2 EGFR EIF2AK3 ENPP1 enterobius vermicularis Epstein Barr ethambutol Fabry Faciogenital dysplasia faecal immunochemichal test faeces FAI Familial Hepatic Adenomas Familial Isolated Hyperparathyroidism Familial Isolated Pituitary Adenoma Familial Medullary Thyroid Carcinoma Familial Partial Lipodystrophy Familial Porencephaly Fanconi-Bickel Syndrome FASP Feingold Syndrome fetal FGD1 FGF23 FIPA first trimester screening FIT FIT; qFIT; occult blood flu flucloxacillin flucytosine FOB foetal FOXP3 FPLD free light chains FSLC FTS fβ-hCG GACI GALNT3 ganciclovir GCK Generalised Arterial Calcification of Infancy gentamicin GFR Glandular fever Glucose Galactose Malabsorption GLUD1 glycine GNPAT Golim GSDII HADH Haemochromatosis Hajdu-Cheney Syndrome hCG Herpes HES7 HFE HFTC HHRH HLA HLA-B27 HLAB27 HNF1A HNF1B HNF4A HR HSV Hutchinson-Gilford Progeria syndrome Hyperinsulinism hyperphosphataemic hyperphosphataemic familial tumoral calcinosis Hyperphosphatemic Familial Tumoral Calcinosis Hypophosphatemic rickets Hypophosphatemic rickets with hypercalciuria immunoassay immunosuppressant Infectious mononucleosis influenza influenzae interference IPEX Syndrome Irinotean therapy Irinotecan Toxicity isoniazid itraconazole IVIg JAG1 KCNJ11 KL KRAS Leucocyte (White Blood Cell) Enzymes levels LFNG LFT LFTs LGMD1B Limb girdle muscular dystrophy type 1B linezolid liver function tests LMNA MAD MAD subtype A MAD subtype B MADA MADB Malignant Melanoma Mandibuloacral dysplasia Mandibulofacial dysostosis with microcephaly Maternally Inherited Diabetes and Deafness Maturity-Onset Diabetes of the Young MELAS Syndrome MEN1 MEN2A MEN2B MEN4 MESP2 Metastatic Colorectal Cancer MFDM mitochondrial mutation m.3243A>G MODY Molecular Genetics monospot MPO Multiple Endocrine Neoplasia Multiple Endocrine Neoplasia Type 1 multiple endocrine neoplasia type 2a multiple endocrine neoplasia type 2b Multiple Endocrine Neoplasia Type 4 MYCN mycobacteria nbt NDH Syndrome needle Needlestick Neonatal Diabetes Neonatal Diabetes Mellitus Neonatal Diabetes Mellitus & Cerebellar Agenesis Neonatal Diabetes Mellitus & Congenital Hypothyroidism (NDH Syndrome) Nestor-Guillermo Progeria Syndrome netilmicin Newsletter NGPS Non-Small Cell Lung Cancer normetanephrine NOTCH2 NOTCH2 exon 34 NOTCH3 NRAS NSCLC NTproBNP; NT-Pro-BNP Nucleocapsid antigen (anti-N) NUDT15 occult blood PAPP A PAPPA Paraganglioma Patau's syndrome PCR penicillin PEX7 PHA2 Phaeochromocytoma Phaeochromocytoma & Paraganglioma PHEX plasma metadrenalines plasma metanephrines plasma mets PLIN1 Pompe porph porphyria porphyrin porphyrins posaconazole PPARG PR3 Prediction of Irinotecan Toxicity PRKAR1A pro BNP Pseudohypoaldosteronism Type 2 Pseudoxanthoma Elasticum PTF1A PTFR PXE qFIT RAS RAST RCAD renal Renal Cysts and Diabetes renal function renal profile respiratory Restrictive Dermopathy RET rifampicin SARS-CoV SARS-CoV-2 SARS-CoV2 SCD type 1 SCD type 2 SCD type 3 SCD type 4 screening programme self-swab sellotape slide sflc SHBG; FAI Simponi sirolimus SL19A2 SLC2A2 SLC34A3 SLC5A1 Spike antigen (anti-S) Spondylocostal dysostosis Staff testing stick stool streptomycin sulphamethoxazole SUR1 SWAG T13 t18 T21 tb TDM teicoplanin Thiamine Responsive Megaloblastic Anaemia thiopurine toxicity thread worms thyroglobulin antibodies tobramycin Toxicty TPMT TRAb TRAbs trimethoprim TRMA Troponin tuberculosis ucpcr UGT1A1 urine hCG Urine pregnancy test USP vaccines (Pfizer vancomycin Varicella Virology Vitamin B7 voriconazole VZV WCE Werner Syndrome White cell enzymes whooping cough WNK4 Wolcott Rallison Syndrome WRN ZMPSTE24 α-glucosidase β-hCG