GENETIC TESTING OF THE TPMT AND NUDT15 GENES TO PREDICT TOXICITY IN PATIENTS TREATED WITH THIOPURINES Thiopurines are used as anticancer agents and as immunosuppressants in inflammatory bowel disease, rheumatoid arthritis and other autoimmune conditions. Three thiopurines are used clinically: azathioprine (a prodrug for mercaptopurine), mercaptopurine, and thioguanine. Thiopurine methyltransferase (TPMT) catabolizes thiopurines. Single nucleotide […]
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