Blood Sciences Test


Allergy Testing

Specimen

Serum

Special Instructions

Minimum sample volume: 3ml

Factors affecting results

If the total IgE is very high (>1000kU/l) allergy testing becomes inaccurate due to non-specific binding.

Test Usage

Testing for IgE antibodies to specific allergens is indicated in patients with symptoms consistent with type 1 hypersensitivity reactions (IgE mediated). The request must specify which allergens are to be tested, where there is doubt please discuss with the laboratory or with an immunologist.

Allergen specific IgE results are reported as classes 0-6 (0 = no detectable specific IgE, 6 = very high levels of specific IgE). Interpretation of results requires clinical assesment, the presence of specific IgE indicates sensitization but does not give information regarding the severity of reactions.

The normal range of total IgE is very wide and levels correlate poorly with clinical disease. If the total IgE is very high (>1000kU/l) allergy testing becomes inaccurate due to non-specific binding.

A high specific IgE to a single allergen may occur with a total IgE in the normal range.

Turnaround time

The turn around time of these tests is variable. Please contact the immunology department to discuss these cases.

Availability

In House / Referred (dependant upon specific request)

Clinical Advice

Clinical advice is available from the Immunology Medical Team at Derriford Hospital

T: 01752 431675

E: plh-tr.eden@nhs.net

 

 

Specimen Labelling Procedure