Anti-neutrophil cytoplasmic antibodies (ANCA)

Specimen

Serum

Factors affecting results

None known

Reference Range

MPO Antibodies

• Negative: ≤5.0 IU/ml
• Positive:   >5.0 IU/ml

PR3 Antibodies

• Negative: ≤3.0 IU/ml
• Positive:   >3.0 IU/ml

Test Usage

C-ANCA and P-ANCA can be seen in ANCA associated vasculitis. The diagnosis should be confirmed histologically wherever possible.

MPO and PR3 antibodies are cascaded automatically by the Immunology laboratory as necessary on ANCA positive patients.

Turnaround time

7 days

Availability

The Immunology laboratory provides this test routinely within normal working hours (09:00–17.30 Monday to Friday). A limited weekend service is offered for clinically urgent ANCA (MPO/PR3 only) and GBM requests; this is normally provided on Saturday only, however a Sunday-only service is provided on bank holiday weekends. A named consultant is required for all urgent requests.

 Clinical Advice

Clinical advice is available from the Immunology Medical Team at Derriford Hospital

T: 01752 431675

E: plh-tr.eden@nhs.net