Serum, collected at least 6 hours after the dose. Please provide details of the daily dosage, the time of the last dose and the sample time.
0.5 – 1.0 ug/L
Monitoring of the digoxin concentration is not indicated in the majority of patients on maintenance treatment, especially if a clear therapeutic response has been obtained, but it may be valuable in certain circumstances :
When there is an initial poor response to treatment
The laboratory also measures and reports both creatinine and potassium on each request for digoxin. Creatinine is analysed to assess renal function, and thus potential impaired elimination of the drug. Potassium is analysed because hypokalaemia is associated with an enhanced response to cardiac glycosides, so digoxin toxicity can occur even within the quoted therapeutic range if the potassium is low.
Can be added on to an existing request up to 4 days following sample receiptSpecimen Labelling Procedure