All samples should be in generally good condition, free from haemolysis and non-lipaemic
Many autoantibodies can be detected on Hep2, liver, kidney and stomach sections so they may be used as the initial autoantibody screening substrates. Autoantibodies detected include nuclear (including centromere), mitochondrial, smooth muscle and liver kidney microsomal.
High titres of anti-nuclear antibodies are found in patients with connective tissue or rheumatic diseases such as systemic lupus erythematosus. High titres of mitochondrial antibodies are found in cases of primary biliary cirrhosis. Low titre antibodies may be present in other liver diseases such as chronic active hepatitis. Anti-smooth muscle antibodies are found at high titre in 70% of patients with chronic active hepatitis. Low titre antibodies may be found in the sera of patients with viral infections, malignancies and in the normal population. Anti-liver kidney microsomal antibodies are found in patients with various types of hepatitis.
Clinical advice is available from the Immunology Medical Team at Derriford Hospital
T: 01752 431675Specimen Labelling Procedure