Blood Sciences Test


Methaemoglobin

PLEASE NOTE THAT BLOOD GAS ANALYSIS IS NOT AVAILABLE FROM THE BLOOD SCIENCES LABORATORY

Specimen

Heparinised blood in a commercial blood gas syringe.

Test Usage

Methaemoglobin is present in erythrocytes (less than 0.5 g/dl) where t is formed during glycolysis and constantly reconverted to haemoglobin. Increased amounts cause a shift in the oxygen dissociation curve to the left so tissues receive less oxygen.

Methaemoglobin is liberated from cells during intravascular haemolysis and can be filtered by the kidneys in the same way as haemoglobin (HB) which in turn can be converted to Methaemoglobin after it has passed into the urine.

Pathological increases in Methaemoglobin may be due to drugs that enhance its synthesis or depress its conversion to Hb.

A reduced conversion of Methaemoglobin to Hb also occurs in congenital methaemoglobinia

Epidemiology

Genetics

Clinical Presentation

Availability

Local test

Turnaround Time

1 day

Cannot be added on to an existing request

Accreditation

Please note this test is not UKAS accredited

Specimen Labelling Procedure