Minimum sample volume: 3 ml
Muscle specific tyrosine kinase (MuSK) is a surface membrane enzyme that is essential in aggregating Acetylcholine receptor during the development of the neuromuscular junction. Recent studies have shown that antibodies to MuSK are present in 40% to 50% of patients with generalised Acetylcholine Receptor seronegative myasthenia gravis. Anti-MuSK antibodies have not been found in patients with purely ocular myasthenia or in those with anti-acetylcholine receptor antibodies.
This investigation is performed at the Immunology Department, Churchill Hospital, Headington, Oxford, OX3 7LJ