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Prostate Specific Antigen – PSA

Blood Sciences Test



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Special Instructions

Prostate Cancer Risk Management Programme



Reference range

Age Ref. range
Up to 50 years 0 – 2.5 µg/L
50 – 60 years 0 – 3.0 µg/L
60 – 70 years 0 – 4.0 µg/L
Over 70 years 0 – 5.0 µg/L

Test Usage

PSA is a single chain glycoprotein (MW 34 000 Daltons) produced by prostatic acinar cells and ductal epithelium. Its physiological function is to act as a protease, dissolving the coagulum after ejaculation.
It has an established role in the monitoring of prostatic neoplasia.

It can also be useful in the diagnosis of prostatic cancer, but in common with other tumour markers, it has problems of sensitivity (i.e. false negatives) and specificity (i.e. false positives) – most often relating to benign prostatic hypertrophy (BPH). When used for diagnosis, it is recommended that the patient be fully counselled about the test limitations, result significance and available treatments before taking the blood sample. At present, there does not seem to be a role for PSA in screening of the asymptomatic population.


Local test

Turnaround Time

1 day

Can be added on to an existing request up to 4 days following sample receipt

Minimum Repeat Interval

13 days

Specimen Labelling Procedure
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