Blood Sciences Test


C Peptide (Plasma)

Specimen

Plasma EDTA 2.7 ml tube or centrifuged serum-gel tube.

Special Instructions

Must be sent to arrive to us at the laboratory within 24 h from collection. If the sample cannot be sent to us within 24 h from sample collection, centrifuge, aliquot and freeze sample and send specimen frozen.

Units

pmol/L

Test Usage

C-peptides are fragments derived from endogenous, but not exogenous, insulin and therefore may be used to assess endogenous insulin secretion even in patients who receive exogenous insulin therapy.

C-peptide testing is used in the investigation of unexplained hypoglycaemia and in the management of patients with insulin treated diabetes.

Investigation of hypoglycaemia:

A C-peptide concentration greater than 300 pmol/L during a hypoglycaemic episode (concurrant glucose <2.5 mmol/L),  is inappropriately high suggesting insulinoma or sulfonylurea ingestion. C-peptide is considered appropriately supressed if less than 94 pmol/L during hypoglycaemia. Indeterminate values (94-300 pmol/L) require measurement of beta hydroxybutyrate to determine if hyperinsulinism is present.

Management of Insulin treated diabetes

C-peptide measurement can assist classification and management of patients who have insulin treated diabetes. Clinical thresholds and interpretation for patients with insulin treated diabetes are shown in table 1 below. As the main clinical role of the C-peptide test in diabetes is identifying or excluding very severe insulin deficiency (present in longstanding Type 1 diabetes and associated with an absolute requirement for insulin) the role of C-peptide testing in non-insulin treated patients is limited

General interpretation

C-peptide ranges

 

Availability

Local test

Turnaround Time

7 days

Cannot be added on to an existing request

 

REFERRALS

We welcome referrals for C-peptide monitoring. If you are a new requestor please complete the following form: New Requestor Form v3

Our Quality Statement for referred work can be found here : Referred Work Quality Statement

Specimen Labelling Procedure